Honkonqun Insilico Medicine \u015firk\u0259ti bildirib ki, onun s\u00fcni z\u0259kan\u0131n k\u00f6m\u0259yi il\u0259 yaratm\u0131\u015f oldu\u011fu d\u0259rman preparat\u0131n\u0131n insanlar \u00fcz\u0259rind\u0259 kliniki testl\u0259rin\u0259 icaz\u0259 verilib. M\u0259lumatda qeyd edilib ki, s\u00fcni z\u0259kan\u0131n k\u00f6m\u0259yil\u0259 yarad\u0131lm\u0131\u015f d\u0259rman preparat\u0131 idiopatik a\u011fciy\u0259r fibrozu x\u0259st\u0259liyinin m\u00fcalic\u0259si \u00fc\u00e7\u00fcn n\u0259z\u0259rd\u0259 tutulub. D\u0259rman hal-haz\u0131rda AB\u015e v\u0259 \u00c7ind\u0259ki x\u0259st\u0259xanalarda \u00fcmumilikd\u0259 60 n\u0259f\u0259r pasient \u00fcz\u0259rind\u0259 test edilir. Insilico Medicine \u015firk\u0259ti bildirib ki, s\u00f6z\u00fcged\u0259n d\u0259rman preparat\u0131n\u0131n haz\u0131rlanmas\u0131na c\u0259mi 18 ay vaxt s\u0259rf edilib. Ad\u0259t\u0259n is\u0259 yeni d\u0259rman preparatlar\u0131n\u0131n haz\u0131rlanmas\u0131na ill\u0259rl\u0259 zaman laz\u0131m olur. \u0130diopatik a\u011fciy\u0259r fibrozu x\u0259st\u0259liyi y\u00fcks\u0259k ya\u015f kateqoriyas\u0131na daxil olan insanlar\u0131n h\u0259yatlar\u0131na son qoyur v\u0259 bu x\u0259st\u0259liyin t\u0259bi\u0259ti bar\u0259sind\u0259 h\u0259l\u0259 d\u0259 bir m\u0259lumat yoxdur.<\/p>\n
Bu x\u0259st\u0259likl\u0259 \u00fcz-\u00fcz\u0259 g\u0259l\u0259n insanlar a\u011fciy\u0259r \u00e7at\u0131\u015fmazl\u0131\u011f\u0131ndan \u0259ziyy\u0259t \u00e7\u0259kirl\u0259r v\u0259 n\u0259tic\u0259d\u0259 h\u0259yatlar\u0131n\u0131 itirirl\u0259r. Honkonqda 2012-ci ild\u0259 Aleksandr Aleksandrovi\u00e7 Javoronkov t\u0259r\u0259find\u0259n t\u0259sis edilmi\u015f Insilico Medicine \u015firk\u0259ti \u00f6z f\u0259aliyy\u0259tinin \u0259vv\u0259lind\u0259n molekullar\u0131n sintezi \u00fc\u00e7\u00fcn generativ s\u00fcni z\u0259ka modell\u0259rind\u0259n istifad\u0259 etm\u0259y\u0259 ba\u015flay\u0131b. \u0130lk \u00f6nc\u0259 t\u0259dqiqat\u00e7\u0131lar f\u0259rdi s\u00fcni z\u0259ka platformas\u0131nda alqoritm\u0259 a\u011fciy\u0259rl\u0259rd\u0259 destruktiv prosesl\u0259rd\u0259n cavabdeh olan h\u0259d\u0259fl\u0259rin t\u0259yin edilm\u0259sini \u00f6yr\u0259dibl\u0259r. Bunun \u00fc\u00e7\u00fcn fibroz bar\u0259sind\u0259 olan m\u0259lumatlardan istifad\u0259 edilib. Bu x\u0259st\u0259lik toxumalar\u0131n qal\u0131nla\u015fmalar\u0131na v\u0259 ya onlarda yara izl\u0259rinin \u0259m\u0259l\u0259 g\u0259lm\u0259sin\u0259 \u015f\u0259rait yarad\u0131r. Bu is\u0259 \u00f6z n\u00f6vb\u0259sind\u0259 a\u011fciy\u0259rl\u0259r d\u0259 daxil olmaqla dig\u0259r orqanlar\u0131n elastiklikl\u0259rini a\u015fa\u011f\u0131 sal\u0131r.<\/p>\n
Fibroz xroniki iltihablara g\u0259tirib \u00e7\u0131xaran qocalma prosesi il\u0259 s\u0131x \u0259laq\u0259lidir. T\u0259dqiqat\u00e7\u0131lar\u0131n aparm\u0131\u015f olduqlar\u0131 analiz n\u0259tic\u0259sind\u0259 TNIK adl\u0131 z\u00fclal m\u00fc\u0259yy\u0259n edilib v\u0259 bu z\u00fclal \u0259sas antifibrotik h\u0259d\u0259f qismind\u0259 \u00e7\u0131x\u0131\u015f edib. N\u00f6vb\u0259ti m\u0259rh\u0259l\u0259d\u0259 laz\u0131mi d\u0259rman preparat\u0131n\u0131n haz\u0131rlanmas\u0131na namiz\u0259d olan 80 \u0259d\u0259d molekulun yarad\u0131lmas\u0131 \u00fc\u00e7\u00fcn generativ kimy\u0259vi alqoritmd\u0259n istifad\u0259 edilib. 80 \u0259d\u0259d namiz\u0259d aras\u0131nda m\u00fct\u0259x\u0259ssisl\u0259r INS018_055 adl\u0131 inhibitoru (fizioloji v\u0259 fiziki-kimy\u0259vi prosesl\u0259rin gedi\u015fini l\u0259ngid\u0259n v\u0259 ya saxlayan madd\u0259l\u0259rin \u00fcmumi ad\u0131d\u0131r) se\u00e7ibl\u0259r. N\u0259tic\u0259d\u0259 bu inhibitor \u0259sas\u0131nda m\u00fcvafiq d\u0259rman preparat\u0131 haz\u0131rlan\u0131b v\u0259 onun farmokoloji \u00f6z\u0259llikl\u0259ri 60 n\u0259f\u0259r pasient \u00fcz\u0259rind\u0259 yoxlan\u0131l\u0131r.<\/p>\n
technote.az<\/p>\n","protected":false},"excerpt":{"rendered":"
Honkonqun Insilico Medicine \u015firk\u0259ti bildirib ki, onun s\u00fcni z\u0259kan\u0131n k\u00f6m\u0259yi il\u0259 yaratm\u0131\u015f oldu\u011fu d\u0259rman preparat\u0131n\u0131n insanlar \u00fcz\u0259rind\u0259 kliniki testl\u0259rin\u0259 icaz\u0259 verilib. M\u0259lumatda qeyd edilib ki, s\u00fcni z\u0259kan\u0131n k\u00f6m\u0259yil\u0259 yarad\u0131lm\u0131\u015f d\u0259rman preparat\u0131 idiopatik a\u011fciy\u0259r fibrozu x\u0259st\u0259liyinin m\u00fcalic\u0259si \u00fc\u00e7\u00fcn n\u0259z\u0259rd\u0259 tutulub. D\u0259rman hal-haz\u0131rda AB\u015e v\u0259 \u00c7ind\u0259ki x\u0259st\u0259xanalarda \u00fcmumilikd\u0259 60 n\u0259f\u0259r pasient \u00fcz\u0259rind\u0259 test edilir. Insilico Medicine \u015firk\u0259ti […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[77],"tags":[],"_links":{"self":[{"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/posts\/211942"}],"collection":[{"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/comments?post=211942"}],"version-history":[{"count":2,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/posts\/211942\/revisions"}],"predecessor-version":[{"id":211944,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/posts\/211942\/revisions\/211944"}],"wp:attachment":[{"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/media?parent=211942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/categories?post=211942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/tags?post=211942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}