Almaniyal\u0131 t\u0259dqiqat\u00e7\u0131lar a\u015fkar edibl\u0259r ki, b\u0259d\u0259nin h\u0259rar\u0259tinin azalmas\u0131 qocalma prosesinin s\u00fcr\u0259tin\u0259 v\u0259 z\u00fclallar m\u00fcbadil\u0259sind\u0259 ya\u015fla ba\u011fl\u0131 d\u0259yi\u015fiklikl\u0259r\u0259 t\u0259sir g\u00f6st\u0259rir.<\/p>\n
B\u0259d\u0259n h\u0259rar\u0259tinin orta d\u0259r\u0259c\u0259d\u0259 a\u015fa\u011f\u0131 d\u00fc\u015fm\u0259si h\u0259m soyuqqanl\u0131, h\u0259m d\u0259 istiqanl\u0131 orqanizml\u0259r\u0259, o c\u00fcml\u0259d\u0259n insan orqanizmin\u0259 yax\u015f\u0131 t\u0259sir g\u00f6st\u0259rir. Lakin aliml\u0259r b\u0259d\u0259n h\u0259rar\u0259tinin azalmas\u0131 hal\u0131nda uzun\u00f6m\u00fcrl\u00fcl\u00fcy\u00fc art\u0131ran m\u00fc\u0259yy\u0259n mexanizml\u0259r haqq\u0131nda indiy\u0259d\u0259k az m\u0259lumatl\u0131 olublar v\u0259 bu da h\u0259min bilikl\u0259rin t\u0259cr\u00fcb\u0259d\u0259 istifad\u0259sini m\u0259hdudla\u015fd\u0131r\u0131r.<\/p>\n
Soyuq il\u0259 uzun\u00f6m\u00fcrl\u00fcl\u00fck aras\u0131nda ba\u011fl\u0131l\u0131\u011f\u0131 \u00f6yr\u0259nm\u0259kd\u0259n \u00f6tr\u00fc Almaniyan\u0131n K\u00f6ln Universitetind\u0259n olan t\u0259dqiqat\u00e7\u0131lar a\u015fa\u011f\u0131 temperaturun h\u00fcceyr\u0259d\u0259 z\u0259d\u0259li v\u0259 laz\u0131ms\u0131z z\u00fclallar\u0131n par\u00e7alanmas\u0131na cavabdeh olan \u00e7oxz\u00fclall\u0131 kompleksl\u0259rin \u2013 proteasomlar\u0131n aktivliyin\u0259 t\u0259sirini \u00f6yr\u0259nibl\u0259r. Proteasomlar\u0131n d\u00fczg\u00fcn aktivliyi h\u00fcceyr\u0259nin f\u0259aliyy\u0259ti \u00fc\u00e7\u00fcn \u00e7ox vacibdir. Par\u00e7alanmaya davam g\u0259tir\u0259n z\u00fclallar\u0131n b\u00f6y\u00fck miqdarda toplanmas\u0131 qocalma il\u0259 ba\u011fl\u0131d\u0131r.<\/p>\n
Aliml\u0259r a\u015fkar edibl\u0259r ki, \u201cCaenorhabditis elegans\u201d tipli dair\u0259vi qurdun normal \u00f6mr\u00fc 20 g\u00fcn oldu\u011fu halda, \u0259g\u0259r o, 15 d\u0259r\u0259c\u0259 Selsi temperaturda saxlan\u0131larsa, \u00f6mr\u00fc 28-29 g\u00fcn\u0259d\u0259k uzan\u0131r. M\u0259lum olub ki, a\u015fa\u011f\u0131 temperaturda h\u00fcceyr\u0259d\u0259 proteasomlar\u0131n f\u0259aliyy\u0259tini t\u0259nziml\u0259y\u0259n v\u0259 h\u00fcceyr\u0259nin \u00f6mr\u00fcn\u00fc uzadan daha \u00e7ox \u201cPSME3\u201d z\u00fclal-aktivatorlar\u0131 yaran\u0131r. \u018fg\u0259r bu h\u00fcceyr\u0259nin f\u0259aliyy\u0259ti t\u0259crid olunarsa, o halda a\u015fa\u011f\u0131 temperatur proteasomlar\u0131n aktivliyin\u0259 s\u0259m\u0259r\u0259li t\u0259sir g\u00f6st\u0259rm\u0259y\u0259c\u0259k. Bu is\u0259 h\u00fcceyr\u0259l\u0259rd\u0259 z\u0259d\u0259li z\u00fclallar\u0131n y\u0131\u011f\u0131lmas\u0131 il\u0259 n\u0259tic\u0259l\u0259n\u0259c\u0259k v\u0259 g\u0259l\u0259c\u0259kd\u0259 ya\u015fla \u0259laq\u0259dar m\u00fcxt\u0259lif x\u0259st\u0259likl\u0259r\u0259 s\u0259b\u0259b ola bil\u0259r.<\/p>\n
Aliml\u0259r g\u00f6st\u0259ribl\u0259r ki, insan h\u00fcceyr\u0259l\u0259rinin a\u015fa\u011f\u0131 temperaturda (36 d\u0259r\u0259c\u0259 Selsi) saxlanmas\u0131 onlarda \u201cPSME3\u201d z\u00fclal\u0131n\u0131n insana aid analoqunu f\u0259alla\u015fd\u0131r\u0131r. Bu, h\u00fcceyr\u0259l\u0259rin \u00f6mr\u00fcn\u00fc uzad\u0131r v\u0259 b\u00fct\u00fcn orqanizmin ya\u015flanma s\u00fcr\u0259tini azald\u0131r. Bel\u0259likl\u0259, a\u015fa\u011f\u0131 sal\u0131nm\u0131\u015f b\u0259d\u0259n h\u0259rar\u0259ti t\u0259kam\u00fcl bax\u0131m\u0131ndan bir-birind\u0259n uzaq orqanizml\u0259rin \u00f6mr\u00fcn\u0259 faydal\u0131 t\u0259sir g\u00f6st\u0259r\u0259 bil\u0259r ki, bu da qocalma prosesinin l\u0259ngidilm\u0259sinin \u00fcmumi mexanizmi kimi ba\u015fa d\u00fc\u015f\u00fcl\u00fcr.<\/p>\n
azertag.az<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" Almaniyal\u0131 t\u0259dqiqat\u00e7\u0131lar a\u015fkar edibl\u0259r ki, b\u0259d\u0259nin h\u0259rar\u0259tinin azalmas\u0131 qocalma prosesinin s\u00fcr\u0259tin\u0259 v\u0259 z\u00fclallar m\u00fcbadil\u0259sind\u0259 ya\u015fla ba\u011fl\u0131 d\u0259yi\u015fiklikl\u0259r\u0259 t\u0259sir g\u00f6st\u0259rir. B\u0259d\u0259n h\u0259rar\u0259tinin orta d\u0259r\u0259c\u0259d\u0259 a\u015fa\u011f\u0131 d\u00fc\u015fm\u0259si h\u0259m soyuqqanl\u0131, h\u0259m d\u0259 istiqanl\u0131 orqanizml\u0259r\u0259, o c\u00fcml\u0259d\u0259n insan orqanizmin\u0259 yax\u015f\u0131 t\u0259sir g\u00f6st\u0259rir. Lakin aliml\u0259r b\u0259d\u0259n h\u0259rar\u0259tinin azalmas\u0131 hal\u0131nda uzun\u00f6m\u00fcrl\u00fcl\u00fcy\u00fc art\u0131ran m\u00fc\u0259yy\u0259n mexanizml\u0259r haqq\u0131nda indiy\u0259d\u0259k az m\u0259lumatl\u0131 olublar v\u0259 bu […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[77],"tags":[],"_links":{"self":[{"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/posts\/44116"}],"collection":[{"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/comments?post=44116"}],"version-history":[{"count":2,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/posts\/44116\/revisions"}],"predecessor-version":[{"id":44118,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/posts\/44116\/revisions\/44118"}],"wp:attachment":[{"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/media?parent=44116"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/categories?post=44116"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.imm.az\/exp\/wp-json\/wp\/v2\/tags?post=44116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}